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Exosomes are endocytic lipid membrane-bound bodies that have been shown to carry proteins associated with cancer and neurodegenerative disease. The ubiquitous presence of exosomes in nearly all biological fluids makes them a promising source of biomarkers for听diagnostic assays based on minimally invasive liquid biopsies. In our group, we are developing novel biosensing platforms based on recognition elements听tailored by molecular self-assembly and tranduction through acoustic wave and electrochemical read-out mechanisms.
Therapeutic drugs monitoring (TDM) is a promising approach towards personalised medicine that optimises efficacy at minimal side effects. For many drugs, the available TDM routes require sample transport to specialised analytical laboratories which renders this approach often unfeasible due to the high cost, long waiting times and complexity of processing.听In our group, we develop novel concepts for bedside drug monitoring technology, enabling optimal dosing in childhood cancer.听This work has recently been recognised by an NIHR Product Development Award (Chromadose), where we听lead a 21-member consortium of academic, industrial and clinical partners.
Key publications:
Acoustic immunosensing of exosomes using a quartz crystal microbalance with dissipation monitoring ()
J听Suthar, E听Parsons, B听Hoogenboom, G听Williams, S听Guldin
Analytical Chemistry, vol. 92, pp. 4082 鈥� 4093 (2020).
A toolkit to quantify target compounds in thin-layer-chromatography experiments ()
S听Ibsen, N听Mac Fhionnlaoich, LA听Serrano, A听Taylor, R听Qi, S听Guldin
Journal of Chemical Education, vol. 95, pp. 2191 鈥� 2196 (2018).
pH-mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma ()
LA Serrano, Y Yang, E Salvati, F Stellacci, S Krol, S Guldin
Chemical Communications vol 54, pp 1485-1488 (2018)
Further infos:
AdReNa group spin-out听Vesynta:
NIHR i4i consortium ChromaDose:
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