Õ¬ÄÐÊÓƵ

XClose

The Comprehensive Clinical Trials Unit at UCL

Home
Menu

OPTIMAS

Visit optimas.org.uk for the up-to-date website.

optimas logo

5 April 2018

Chief Investigator: Professor David Werring (UCL)

OPTIMAS is a multicentre randomised controlled trial of early vs standard, guideline-based timing of anticoagulation Ìýwith a DOAC in patients with atrial fibrillation and acute ischaemic stroke.

Eligibility: Adult patients with nvAF and clinical diagnosis of acute ischaemic stroke, eligible for DOAC treatment.Ìý

Intervention: Anticoagulation with any DOAC within 4 days of acute ischaemic stroke

Control: Anticoagulation with any DOAC at 7—14 days of acute ischaemic stroke

Key Outcomes: combined incidence of symptomatic ICH, ischaemic stroke and systemic embolism at 90 days; intracranial and major extracranial bleeding

Imaging: encouraged but no specific requirements for study entry

First recruit: July 2019
Recruitment to date: 897 (17 May 2021)

Target sites: >100 in UK (115 EoI to date)Ìý
Sites activated to date:
78 (17 May 2021)

Interested? Email ctu.optimas@ucl.ac.ukÌýor visitÌý.

UCL Stroke Research Centre Logo
British Heart Foundation Logo

MRI Scan Image

Ìý

Ìý

Ìý

Publications
  • Jonathan G Best, Liz Arram, Norin Ahmed, Maryam Balogun, Kate Bennett, ÌýEkaterina Bordea, Marta G Campos, Emilia Caverly, ÌýMarisa Chau, Hannah Cohen, Hakim-Moulay Dehbi, ÌýCaroline J Doré, Stefan T Engelter, Robert Fenner, Nick Freemantle, Rachael Hunter, Martin James, Gregory YH Lip, Macey L Murray, Bo Norrving, Nikola Sprigg, Roland Veltkamp, Iwona Zaczyk, David J Werring, the OPTIMAS investigators |Ìý |Ìýdoi.org/10.1177/17474930211057722

Ìý