Deep Phenotyping Clinic

Deep phenotyping - Imaging and functional testing in clinic, remote assessment and wearables

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What?

Deep phenotyping and remote assessment using wearable devices and smartphones will be employed to identify subclinical damage or dysfunction in people experiencing long COVID.

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Why?

We hypothesize that long COVID听will be associated with evidence of multi-organ pathology

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How?

This investigation will involve 300 to 350 participants (long COVID and controls) who will be recruited from existing population cohorts. The following investigations will be carried out:

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Multi-organ听imaging听

Imaging of the brain, lungs, heart,听liver听and kidneys using听magnetic resonance听imaging (MRI)

Functional testing in clinic 听

听Anthropometry听
听Lung function using听spirometry听听
Resting听heart rate variability and electrocardiogram (ECG),听lying, seated, standing brachial听and central听blood pressure (BP)听
Cardiopulmonary exercise testing, including assessment of peak VO2, 12 lead ECG, blood pressure, muscle perfusion using near infrared听spectroscopy, echocardiographic cardiac听output听and pre/post-exercise lactate听
听Retinal Optical Coherence Tomography angiography听听
听Strength and physical performance听
听Blood听and urine听samples听for storage听

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Remote assessment听and wearables

听MassSci听App听for remote assessment听of听physical and mental health fortnightly or monthly, depending on the parameter measured.听
Cognitron听()听for听cognitive function, completed weekly for a month, and subsequently repeated 6 monthly.听
Garmin听vivoactive听4 wrist worn device听to听capture听habitual听activity, heart rate variability, sleep patterns, oxygen saturation (SpO2) and respiratory rate. In addition,听participants will听perform a standardised 6-minute walk test and a chair sit-stand test fortnightly for the听first听6 months, then quarterly. All听remote听assessments will continue for up to 18 months.听

Research Lead: Professor Alun Hughes (UCL)

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