Initiation: Epithelial damage / Endothelial activation / Immune cell infiltration / Inflammation
Progression: Fibroblast proliferation / Fibrocyte recruitment / Epithelial-mesenchymal transition / Ongoing epithelial damage
Failed resolution: Myofibroblast persistence / Altered matricellular interaction / Perturbed epithelial repair / Ongoing epithelial damage ÌýÌý