Research synopsis
The maintenance of the extraordinary neuronal cytoarchitecture relies onthe compartmentalization of gene expression. This allows the neurons to regulate gene expression locally and independently in distant cellular compartments, such as in axon terminals, and respond rapidly to local signals. The 3’untranslated region (UTR) of mRNAs play a fundamental role in regulating many aspects of RNA metabolism including transcript stability, localization and translation. We recently showed () thatTp53inp2, a bifunctional mRNA abundantly expressed and localized in sympathetic neuron axons, is not translated in neuronal cells.ձ53Ա2mRNA is implicated in NGF signaling and is essential for the neuronal survival, axonal growth, and target innervation. However, how this mRNA regulates NGF signaling remains unknown. The long 3’UTR ofTp53inp2mRNA may play a role in this regulation. So, my goal is to understand the mechanisms by whichTp53inp2mRNA coordinates the regulation of NGF signaling and to identify the players that may be responsible for coordinating its bifunctional state.
Biography
Awards
Funders
Wellcome
Research themes
Technology
Light microscopy