լƵ

XClose

Predicting Language Outcome and Recovery After Stroke (PLORAS)

Home
Menu

Selected Publications

2022

Bonkhoff AK, Hope T, Bzdok D, Guggisberg AG, Hawe RL, Dukelow SP, Chollet F, Lin DJ, Grefkes C, Bowman H. Recovery after stroke: the severely impaired are a distinct group. J Neurol Neurosurg Psychiatry. 2022 Apr;93(4):369-378. doi: 10.1136/jnnp-2021-327211. Epub 2021 Dec 22. PMID: 34937750.DOI:

Geva S, Schneider LM, Khan S, Lorca-Puls DL, Gajardo-Vidal A; PLORAS team; Hope TMH, Green DW, Price CJ. Enhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants. Cereb Cortex. 2023 Mar 21;33(7):3437-3453. doi: 10.1093/cercor/bhac282. PMID: 35965059; PMCID: PMC10068299.

Yamamoto AK, Sanjuán A, Pope R, Parker Jones O, Hope TMH, Prejawa S, Oberhuber M, Mancini L, Ekert JO, Garjardo-Vidal A, Creasey M, Yousry TA, Green DW, Price CJ. The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks. Front Hum Neurosci. 2022 May 16;16:803163. doi: 10.3389/fnhum.2022.803163. PMID: 35652007; PMCID: PMC9148966.

RELEASE Collaborators:Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, Pietro-Bachmann MD, Enderby P, Fillingham J, Lucia Galli F, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LM, Kambanaros M, Kyoung Kang E, Khedr EM, Pak-Hin Kong A, Kukkonen T, Laganaro M, Lambon Ralph MA, Charlotte Laska A, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Shisler Marshall R, Mattioli F, Maviş İ, Meinzer M, Nilipour R, Noé E, Paik NJ, Palmer R, Papathanasiou I, Patricio B, Pavão Martins I, Price C, Prizl Jakovac T, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, Harris Wright H.Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis. Int J Stroke. 2022 Dec;17(10):1067-1077. doi: 10.1177/17474930221097477. Epub 2022 May 18. PMID: 35422175; PMCID: PMC9679795.


2021

Ekert, J.O., Lorca-Puls, D.L., Gajardo-Vidal, A., Crinion, J.T., Hope, T.M.H., Green, D.W. Price, C.P. 2021. A functional dissociation of the left frontal regions that contribute to single word production tasks. Neuroimage. .

Ekert, J.O., Gajardo-Vidal, A., Lorca-Puls, D.L., Hope, T.M.H., Dick, F., Crinion, J.T., Green, D.W., Price, C.J. 2021. Dissociating the functions of three left posterior superior temporal regions that contribute to speech perception and production. Neuroimage (in press).

Ekert, J.O., Kirkman, M.A., Seghier, M.L., Green, D.W.,Price, C.J. 2021. A data-based approach for selecting pre- and intra-operative language mapping tasks. Frontiers in Human Neuroscience (in press).

Geva S, Schneider, L.M., Khan, S., Gajardo-Vidal, A., Lorca-Puls, D.L., PLORAS team, Hope, T.M.H., Green, D.W., Price, C.J. 2021.Accurate speech production following cerebellar stroke is associated with enhanced activation in cerebral motor regions.NeuroImage: Clinical..

Lorca-Puls, D., Gajardo-Vidal, A., PLORAS team, Oberhuber, M., Prejawa, S, Hope, TMH, Leff, A.P., Green, D.W., Price, C.J. 2021. Brain regions that support accurate speech production after damage to Broca’s area.Brain Communications..

Geva, S., Schneider, L., Roberts, S., Khan, S., Gajardo-Vidal A.,Lorca-Puls D., PLORAS team, Hope, T.M.H., Green D.W., Price, C.J. 2021. Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas. NeuroImage: Clinical. .

Hope, THM., Nardo, D., Holland, R., Ondobaka, S., Akkad, H., Price, CJ., Leff, A.P., Crinion, J.T. 2021. Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study. Scientific Reports..

Roberts, S., Bruce, R. M.,Lim, L., Woodgate, H., Ledingham, K., Anderson, S., Lorca-Puls, D. L., Gajardo-Vidal, A., Leff, A. P., Hope, T. M. H.,Green, D. W.,Crinion, J. T.& Price, C. P. 2021.Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What’s driving recovery?Neuropsychological Rehabilitation..

Lorca-Puls DL, Gajardo-Vidal A, Green DW, Price CJ. 2021. Reply: Where is the speech production area? Evidence from direct cortical electrical stimulation mapping. .

Geva, S., Schneider, L., Roberts, S., Green D.W., Price, CJ. 2021. The effect of focal damage to the right medial posterior cerebellum on word and sentence comprehension and production. Frontiers Human Neuroscience..

Sajid, N., Holmes, E., Hope, T.M., Fountas, Z, Price, C.J. and Friston, K.J. 2021. Simulating lesion-dependent functional recovery mechanisms. Scientific Reports..

RELEASE Collaboration. 2021. Predictors of post-stroke aphasia recovery: a systematic review-informed individual participant data (IPD) meta-analysis. ٰǰ..

Geva, S., Truneh, T., Seghier, M.L, Hope T.M.H., Leff, A.P., Crinion, J.T., Gajardo-Vidal A., Lorca-Puls D.L., Green D.W., PLORAS team, Price, CJ. 2021. Lesions that do and do not impair digit span: A study of 816 stroke survivors.Brain Communications..

Bowman H., Bonkhoff , A., Hope TMH, Grefkes C., Price C.J. 2021. Inflated Estimates of Proportional Recovery from Stroke: The Dangers of Mathematical Coupling and Compression to Ceiling.ٰǰ..

Gajardo-Vidal A., Lorca-Puls D.L., PLORAS team, Warner H., Bawan, P., Crinion, J.T., Leff, A.P., Hope T.M.H., Geva, S., Seghier, M., Green D.W., Bowman, H., Price, CJ. 2021. Damage to Broca's area does not contribute to long-term speech production outcome after stroke. Brain. .


2020

Upton, E. & Hope, T.M.H. 2020. Moving beyond the dual stream account of language. ..

Hope, T.M.H. 2020.Linear regression. “Machine Learning: Methods and Applications to Brain Disorders”, Vieira, S. & Mechelli, A. (eds), Chapter 4. Elsevier. ISBN-13: 9780128157398, 978-0128157398.

Bonkhoff, A., Hope, T.M.H., Bzdok, D., Guggisberg, A.G., Hawe, R.L., Dukelow, S.P., Rehme, A.K., Fink, G.R., Grefkes, C. & Bowman, H. 2020. Bringing proportional recovery into proportion: Bayesian hierarchical modelling of post-stroke motor performance. ..

Fleming, V., Brownsett, S., Krason, A., Price, C.J., Crinion, J.T. &Leff, A.P. 2020. Efficacy of spoken word comprehension therapy in patients with chronic aphasia: A cross-over randomised controlled trial with structural imaging. Journal of Neurology, Neurosurgery and Psychiatry. .

Schevenels, K., Price, C. J., Zink, I., De Smedt, B., & Vandermosten, M. 2020. A review on treatment related brain changes in aphasia. Neurobiology of Language..

RELEASE Collaboration. 2020. Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke.Int J Speech Lang Pathol..

Brady, M., Myzoon, A., VandenBerg, K., Williams, L.J. Williams, L.R. and the RELEASECollaboration. 2020. RELEASE: A protocol for a systematic review based, individual participant data meta- and network meta-analysis, of complex speech-language therapyinterventions for stroke-related aphasia.󲹲DZDz..

Twomey, T., Price, C.J., Waters, D., MacSweeney, M. 2020. The impact of early language exposure on the neural system supporting language in deaf and hearing adults. ܰDZ..

Sajid N, Parr T, Gajardo-Vidal A, Price CJ, Friston KJ. 2020. Paradoxical lesions, plasticity and active inference. Brain Commun. .

Sajid N, Friston KJ, Ekert JO, Price CJ, W Green D. 2020. Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach. Behav Sci (Basel). .

Sajid, N., Parr, T., Hope, T.M., Price, C.J., Friston, K.J. 2020. Degeneracy and Redundancy in Active Inference. Cerebral Cortex..

Friston, K.J., Sajid, N., Quiroga-Martinez, D.R., Price, C.J., Holmes, E. 2020. Active listening. Hearing Research.

Friston, K.J., Parr, T., Yufik, Y., Price, C.J., Holmes, E. 2020. Generative models, linguistic communication and active inference.Neuroscience and Biobehavioral Reviews..

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizeau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Costello A, Pillay D, Lambert C. 2020. Effective immunity and second waves: a dynamic causal modelling study.Wellcome Open Research.

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizeau J, Hulme OJ, Billig AJ, Litvak V, Moran RJ, Price CJ, Lambert C. 2020.Dynamic causal modelling of COVID-19. Wellcome Open Research..


2019

Loughnan, R., Lorca-Puls, D. L., Gajardo-Vidal, A., Espejo-Videla, V., Gillebert, C. R., Mantini, D., Price, C.J., Hope, T. M. H. 2019.Generalizing post-stroke prognoses from research data to clinical data.Neuroimage: Clinical..

Evans S, Price CJ, Diedrichsen J, Gutierrez-Sigut E, MacSweeney M. Sign and Speech SharePartially Overlapping Conceptual Representations. 2019. Curr Biol. .

Yamamoto AK, Parker Jones O, Hope TMH, Prejawa S, Oberhuber M, Ludersdorfer P, Yousry TA, Green DW, Price CJ. 2019. A special role for the right posterior superior temporal sulcus during speech production. Neuroimage. .

Yamamoto AK, Magerkurth J, Mancini L, White MJ, Miserocchi A, McEvoy AW, Appleby I, Micallef C, Thornton JS, Price CJ, Weiskopf N, Yousry TA. 2019. Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility. Neuroimage Clin. .

Zeidman P, Jafarian A, Corbin N, Seghier ML, Razi A, Price CJ, Friston KJ. 2019. A guide to group effective connectivity analysis, part 1: First level analysis with DCM for fMRI. Neuroimage. .

Zeidman P, Jafarian A, Seghier ML, Litvak V, Cagnan H, Price CJ, Friston KJ. 2019. A guide to group effective connectivity analysis, part 2: Second level analysis with PEB. Neuroimage. .

Ludersdorfer P, Price CJ, Kawabata Duncan KJ, DeDuck K, Neufeld NH, Seghier ML. 2019. Dissociating the functions of superior and inferior parts of the left ventral occipito-temporal cortex during visual word and object processing. ܰǾ..


2018

Hope, T.M.H., Friston, K.J.,Price, C.J.,Leff, A., Rotstein, P. & Bowman, H. 2018. Brain, 142 (1), 15-22.

Gajardo-Vidal, A., Lorca-Puls, D.L., Hope, T.M.H., Parker Jones, O., Seghier, M.L., Oberhuber, M., Prejawa, S., Crinion, J., Leff, A.P., Green, D.W. &Price, C.J.2018.Brain, 141 (12), 3389-3404.

Hope, T.M.H., Leff, A.P. &Price, C.J. 2018. Neuroimage: Clinical, 19, 22-29.

Seghier, M.L. &Price, C.J. 2018.Trends in Cognitive Sciences,22, 517-530.

Lorca-Puls, D., Gajardo-Vidal, A., White, J., Seghier, M., Leff, A., Green, D., Crinion, J., Ludersdorfer, P., Hope, T., Bowman, H. &Price, C.J. 2018. Neuropsychologia, 115, 101-111.

Gajardo-Vidal, A., Lorca-Puls, D.L., Crinion, J.T., White, J., Seghier, M.L., Leff, A.P., Hope, T.M.H., Ludersdorfer, P., Green, D.W., Bowman, H. &Price, CJ. 2018. Neuropsychologia,115, 124-133.

Aguilar, O.M., Kerry, S.J., Ong, Y-H, Callaghan, M.F., Crinion, J., Woodhead, Z.V.J., Price, C.J., Leff, A.P. &Hope, T.M.H. 2018.Journal of Neurology, Neurosurgery, and Psychiatry,89 (12), 1352-1354.

Price, C.J. 2018.Cortex, 107, 37-49.


2017

Nardo, D., Holland, R., Leff, A.P., Price, C.J. &Crinion, J.T.2017. Brain, 140, 3039-3054.

Achilles, E.I.S., Weiss, P.H., Fink, G.R., Binder, E., Price, C.J. &Hope, T.M.H. 2017. Neuroimage, 161, 94-103.

Woodhead, Z.V.J., Crinion, J., Penny, W., Teki, S., Price, C.J. &Leff, A.P. 2017. Journal of Neurology, Neurosurgery, and Psychiatry, 88, 586-594.

Hope, T.M.H., Leff, A.P., Prejawa, S., Bruce, R., Haigh, Z., Lim, L., Ramsden, S., Oberhuber, M., Ludersdorfer, P., Crinion, J., Seghier, M.L. &Price C.J. 2017. Brain, 140(6), 1718-1728.

Lorca-Puls, D.L., Gajardo-Vidal, A., Seghier, M.L., Leff, A.P., Sethi, V., Prejawa, S., Hope, T.M.H., Devlin, J.T. and Price, C.J. 2017. Brain,140(6),1729-1742.

Price, C.J., Hope, T.M., Seghier, M.L. 2017. Neuroimage, 145(B),200-208.


2016

Hope, T.M., Seghier, M.L., Prejawa, S., Leff, A.P., Price, C.J. 2016. Neuroimage,125,1169-1173.

Seghier, M.L., Patel, E., Prejawa, S., Ramsden, S., Selmer, A., Lim, L., Browne, R., Rae, J., Haigh, Z., Ezekiel, D., Hope, T.M., Leff, A.P., Price, C.J. 2016.Neuroimage,124(B),1208-1212.


2015

Hope, T.M., Parker Jones, O., Grogan, A., Crinion, J., Rae, J., Ruffle, L., Leff, A.P., Seghier, M.L., Price, C.J., Green, D.W. 2015.Brain, 1-14.


2014

Seghier, M.L., Ramsden, S., Lim, L., Leff, A. P. and Price, C. 2014.Stroke,45, 877-879.


2013

Hope, T., Seghier M., Leff, A. and Price, C. 2013.NeuroImage: Clinical, 2(1), 424-433.

Overview

  • This paper presents amethod that combinestheinfluence of stroke,time post strokeanddemographic informationin a large group of stroke patients topredictthe likely course of recovery over timein new patients.

2010

Ambridge, L., Leff, A., Crinion, J., and Price, C. October 2010.Predicting language outcome and recovery after stroke.Royal College of Speech & Language Therapists Bulletin, 12-15.

Overview

  • This article was written for theRoyal College of Speech & Language Therapists Bulletin.
  • It gives anoverviewof thereasons for the project, themethodsused, and somefindings.

Price, C., Seghier, M., and Leff, A. 2010.Nature Reviews Neurology,6,202-210.

Overview

  • This paper presents anew approach for predicting language outcome and recoveryafter stroke.
  • Itcompares the practicality of two different possibilities.
  • Theinitial perspectivewas tounderstand the neural circuits that support language(the wiring in the brain) but this is a complicated endeavour.
  • Thenew methodismore pragmaticandmakes predictions on the basis of the recovery of previous patients with the same type of stroke.
  • This methodrequires a databasethatrecords the speech and language skills of a large group of patientswho have arange of stroke sites.
  • It alsorequires a very precise and accurate way of measuring the location and extent of the lesioninthree dimensional high definition space.

Price, C., Crinion, J., Leff, A., Richardson, F., Schofield, T., Prejawa, S., Ramsden, S., Gazarian, K., Lawrence, M., Ambridge, L., Andric, M., Small, S. and Seghier, M.2010.Lesion sites that predict the ability to gesture how an object is used.Archives Italiennes de Biologie,148(3), 243-258.

Overview

  • This study combined three methodologies to identifythebrain regions where damage impairs the ability to gesture how an objectis movedwhile preserving the ability to recognisethe object and move the hands.
  • The results demonstrate thatthe mapping between lesion site and symptoms is notone-to-one, becausedifferent lesion sites can cause the same symptom and different symptoms can result from the same lesion site, depending on the degree of damage to other areas. For example, the effect of losing the use of your index finger depends on whether or not the other fingers can still be used.
  • The take home message is that predicting outcome from lesion sites requires a consideration ofthe combination of regions thatare damaged.

2008

Seghier, M., Ramlackhansingh, A., Crinion, J., Leff, A. and Price, C. 2008.Neuroimage,41, 1253.

Overview

  • This paper introduces anew procedure for identifying stroke sitesfrom MRI scan images of the brain.
  • This procedure is able todetect stroke sites with different sizes, locations, and textures.
  • The approach canhelp to explain how different stroke sites affect behaviourof a stroke survivor (such as language skills)
  • The method should help tofind the total volume of the stroke siteor tofind the exact boundaries of the stroke. Thiscould be useful for surgical purposesordiagnosing problems.

2002

Price, C. and Friston, K. 2002.Degeneracy and cognitive anatomy.Trends in Cognitive Sciences,6(10), 416-421. . Contact Usfor the full text.

Overview

  • This paper wasfundamental in shaping our approach to understanding the relationship between lesion site and cognitive deficit.
  • Thecore ideais thatthe brain has different ways of doing the same thing. This issimilartoknowing that it is possible to write using either the left or the right hand. If welose the left hand, we becomemore reliant on the right hand, and if we lose the right hand, we can use our left hand (with practice).
  • Thesealternative ways of doing the same thing are available in the healthy brain (or body) but there are a limited number of options. For example, if youlose the use of both your right and left handthen you may need tolearn to write with a pen in your mouth or your toes. There are not an infinite number of viable options and the alternative possibilities may be laborious.
  • Recovery therefore depends on the availability of efficient options.
  • In terms of methodology, the paper proposes a way tounderstand and delineate the sets of brain regions that can support a particular function.
  • However, as described in more recent papers (see above), we now think that it ismore effective to predict outcome and recovery using a pragmatic database approach as opposed to understanding all the underlying theory.
  • Likewise, although it isimportant that you know that your car won't start if the engine's battery is dead, adriver does not need to know how the battery or the engine work.