In the Linden Lab, based at the UCL Ear Institute, we research the brain mechanisms of listening.
Our work
We investigate how complex, temporally varying sounds (such as speech) are represented and analysed by neurons in the auditory cortex and thalamus.
We also study how brain mechanisms of listening are disrupted in mouse models of human schizophrenia, tinnitus and auditory processing disorder.
Our goal is to translate fundamental discoveries in mice into new tools and treatments for improving listening ability in humans. Experimental methods include electrophysiological recording, computational modelling, and auditory behavioral testing in mice and humans.
Research projects
We believe the best science and greatest impact arises from cross-fertilisation of ideas, between people and across disciplines. Our projects听are interdisciplinary, and involve collaborations with colleagues at UCL and/or around the world. Find out about our current projects
- Brain mechanisms of listening
- Auditory brain abnormalities in developmental disorders
- Auditory brain abnormalities in schizophrenia
- Other ongoing work
Find out more about our research.
笔别辞辫濒别听
Adele Simon, postdoctoral student
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Eleanor Benoit, rotation student
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Lara Carvalho Sauer, MSc Advanced Audiology project student
Lior Fox,听postdoctoral fellow听
Selected recent publications
- Lu C and Linden JF (2023).听听bioRxiv,听doi: 10.1101/2023.10.04.560916.
- Akritas M, Armstrong AG, Lebert JM, Meyer AF, Sahani M and Linden JF (2023). 听bioRxiv听2023.04.22.537782; doi: 10.1101/2023.04.22.537782.
- Linden JF (2023). Sensory representations in the auditory cortex and thalamus. Section 5, Chapter 7 in: Usrey WM (Ed.), Sherman CM (Ed.), Hirsch J (Section Ed.) and King AJ (Section Ed.),听The Cerebral Cortex and Thalamus.听Oxford University Press, in press.
- Zinnamon FA, Harrison FG, Wenas S, Liu Q, Wang KH and Linden JF (2023). 听Biological Psychiatry: Global Open Science, 3:386-397.
- Wang B, Zartaloudi E, Linden JF and Bramon E (2022).听 听Translational Psychiatry, 12(1):100.
- Gothner T, Goncalves PJ, Sahani M, Linden JF and Hildebrandt KH (2021). 听Cerebral Cortex听31(5):2364-2381.
- Kopp-Scheinpflug C and Linden JF (2020). Coding of Temporal Information. In: Fritzsch B (Ed.) and Grothe B (Volume Ed.),听The Senses: A Comprehensive Reference, Volume 2 (Audition).听Elsevier, Academic Press, pp. 691-712. (Contact听j.linden@ucl.ac.uk听to request a reprint.)
- Zinnamon FA, Harrison FG, Wenas SS, Meyer AF, Liu Q, Wang KH and Linden JF (2019). 听bioRxiv听doi: 10.1101/539650.
- Meyer AF*, Poort J*, O'Keefe J, Sahani M and Linden JF (2018). 听Neuron听100:46-60.e7.听*equal contributions
- Kopp-Scheinpflug C, Sinclair JL and Linden JF (2018). Trends in Neurosciences听41:712-728.
- Anderson LA*, Hesse LL*, Pilati N*, Bakay WMH, Alvaro G, Large CH, McAlpine D, Schaette R, and Linden JF (2018). 听Hearing Research听365:77-89.听*equal contributions
- Hildebrandt KJ, Sahani M and Linden JF (2017). 听Frontiers in Systems Neuroscience, 29 November 2017, doi:10.3389/fncir.2017.00095.听
- Guidi LG, Mattley J, Martinez-Garay I, Monaco AP, Linden JF, Velayos-Baeza A and Molnar Z (2017). 听Cerebral Cortex听17:1-15.
- Burgess CP, Lak A, Steinmetz N, Zatka-Haas P, Reddy CB, Jacobs E, Linden JF, Paton JJ, Ranson A, Schroeder S, Soares S, Wells M, Wool LE, Harris KD, Carandini M (2017).听 Cell Reports听20(10): 2513-2524.
- Linden JF (2017). 听Neuron听95(1): 3-5.
- Meyer AF, Williamson RS, Linden JF and Sahani M (2017). 听Frontiers in Systems Neuroscience听10(109), doi: 10.3389/fnsys.2016.00109.听
- Hesse LL, Bakay W, Ong HC, Anderson LA, Ashmore J, McAlpine D, Linden JF and Schaette R (2016). 听Frontiers in Neurology听7(133), doi: 10.3389/fnrur.2016.00133.听
- Williamson RS, Ahrens M, Linden JF* and Sahani M* (2016). 听Neuron听91(2): 467-71.听*equal contributions
- Anderson LA and Linden JF (2016). 听Journal of Neuroscience听36(6): 1977-95.
View older publications
Funding
We are grateful to have received funding for past projects from the following bodies:
Currently, our research on fundamental brain mechanisms of listening is funded by the BBSRC, and our translational work on development of new algorithms to improve human listening ability is funded by the NIHR-UCLH Biomedical Research "Hearing Health" Theme.
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